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One current research from Yale University found that vanillin — an extract of the vanilla bean — transforms into chemicals known as acetals when aerosolized. Those chemicals, the researchers stated, could also be particularly irritating to the lungs and cause harm when inhaled. Studies have shown that breathing in aerosolized propylene glycol may contribute to bronchial asthma. And a 2012 case report concerned a girl who developed a situation called exogenous lipoid pneumonia after vaping for about six months.